Lethality of 22 cal bullets

For hunting thin skinned game or 2 legged self-defense. For the military 556 it seems the lethality of the bullet is its ability to destabilize and cause major damage. How does the new 77gr OTM bullet work out in causing damage? What are the thoughts on using an expanding type bullet, designed for hunting, something like a 60gr 22 cal Nosler partition.